کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777698 1152753 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
Determinants of DHA levels in early infancy: Differential effects of breast milk and direct fish oil supplementation
چکیده انگلیسی

IntroductionAlthough omega (n)-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important during infancy, the optimal method of increasing infant status remains unclear. We hypothesized that high-dose infant fish oil supplementation would have greater relative effects upon n-3 LCPUFA status at six months of age than breast milk fatty acids.Patients and methodsInfants (n=420) were supplemented daily from birth to six months with fish oil or placebo. In a subset of infants, LCPUFA levels were measured in cord blood, breast milk and in infant blood at 6 months.ResultsDHA levels increased in the fish oil group relative to placebo (p<05). Breast milk DHA was the strongest predictor of infant erythrocyte DHA levels (p=<001). This remained significant after adjustment for cord blood DHA, supplementation group and adherence.ConclusionIn this cohort, breast milk DHA was a greater determinant of infant erythrocyte n−3 LCPUFA status, than direct supplementation with fish oil.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 86, Issue 6, June 2012, Pages 233–239
نویسندگان
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