کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2777775 | 1152759 | 2012 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice](/preview/png/2777775.png)
n-3 Polyunsaturated fatty acids (PUFA) are increasingly consumed as food additives and supplements; however, the side effects of these fatty acids, especially at high doses, remain unclear. We previously discovered a high fat n-3 PUFA diet made of fish/flaxseed oils promoted significant weight gain in C57BL/6 mice, relative to a control, without changes in food consumption. Therefore, here we tested the effects of feeding mice high fat (HF) and low fat (LF) n-3 PUFA diets, relative to a purified control diet (CD), on locomotor activity using metabolic cages. Relative to CD, the HF n-3 PUFA diet, but not the LF n-3 PUFA diet, dramatically reduced ambulatory, rearing, and running wheel activities. Furthermore, the HF n-3 PUFA diet lowered the respiratory exchange ratio. The data suggest mixed fish/flaxseed oil diets at high doses could exert some negative side effects and likely have limited therapeutic applications.
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 86, Issue 3, March 2012, Pages 137–140