کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2777899 1568035 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Promoter polymorphism (rs17222919, –1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
A Promoter polymorphism (rs17222919, –1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population
چکیده انگلیسی

To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, −1316T/G), PTGES (rs7872802, −404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (rs3842788, Gln41Gln) and PTGS2 (rs5275, 3′UTR). A total of 398 control subjects and 196 stroke patients (79 ICH and 117 IS) were genotyped by direct sequencing. The rs17222919 SNP was associated with ICH in codominant 1 (P=0.008), dominant (P=0.003) and log-additive (P=0.004) models. Allele frequencies of rs17222919 were different between ICH and controls (P=0.007). However, the seven tested SNPs were not associated with clinical phenotypes (NIHSS, MBI and CRPS) in ICH and IS. These results suggest that the promoter SNP rs17222919 of ALOX5AP may be associated with the development of ICH in Korean population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 85, Issues 3–4, September–October 2011, Pages 115–120
نویسندگان
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