کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2778292 | 1152803 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lysophosphatidic acid stimulates inflammatory cascade in airway epithelial cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EGFTNFHASMCHESLPAGM-CSFSfMGAPDHFBSlysophosphatidic acid - اسید لیسفسفیدیدinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینELISA - تست الیزاEnzyme-linked immunosorbent assay - تست الیزاfetal bovine serum - سرم جنین گاوChronic hyperplastic eosinophilic sinusitis - سینوزیت ائوزینوفیلی هیپرپلازی مزمنepidermal growth factor - عامل رشد اپیدرمیHuman airway smooth muscle - عضله صاف انسان راه هواییVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)tumor necrosis factor - فاکتور نکروز تومورgranulocyte macrophage-colony stimulating factor - ماکروفاژ عصبی ماکروفاژ - colony stimulating factorSerum-free medium - محیط بدون سرمNasal polyposis - پولیپوز بینیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nasal polyps are benign outgrowths originating from the anterior ethmoid and maxillary sinuses. The events leading to polyp formation are unknown but evidence points to damage of the mucousal epithelium. Lysophosphatidic acid (LPA) is a water-soluble phospholipid that has been implicated in the development of allergic inflammation. We hypothesized LPA may be an important mediator in the initiation and maintenance of the inflammatory milieu of the polyp. Data was compared from unstimulated lung epithelial and when possible nasal polyp-derived epithelial cells with LPA stimulated cells. LPA receptors 1 and 2 were constitutively expressed on lung and nasal polyp-derived epithelial cells and receptor mRNA expression was decreased upon stimulation with IL-13 and IFN-γ. When cells were treated with LPA, cellular proliferation was stimulated 2.2 fold. Supernatants from LPA stimulated cells displayed decreases in the levels of VEGF, GM-CSF, and TNF-α at 24 h which returned to normal or increased at 48 h. Our results suggest epithelial cells undergo rapid proliferation in response to LPA resulting in a transient decrease in inflammatory cytokines followed by an upregulation of these cytokines that could lead to increased inflammation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 74, Issue 6, June 2006, Pages 357-363
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids - Volume 74, Issue 6, June 2006, Pages 357-363
نویسندگان
Elizabeth Barekzi, Jessica Roman, Kathleen Hise, Steve Georas, John W. Steinke,