کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2784689 1568221 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Positional identity of adult stem cells in salamander limb regeneration
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Positional identity of adult stem cells in salamander limb regeneration
چکیده انگلیسی

Limb regeneration in larval and adult salamanders proceeds from a mound of mesenchymal stem cells called the limb blastema. The blastema gives rise just to those structures distal to its level of origin, and this property of positional identity is reset to more proximal values by treatment with retinoic acid. We have identified a cell surface protein, called Prod1/CD59, which appears to be a determinant of proximodistal identity. Prod1 is expressed in an exponential gradient in an adult limb as determined by detection of both mRNA and immunoreactive protein. Prod1 protein is up-regulated after treatment of distal blastemas with RA and this is particularly marked in cells of the dermis. These cells have previously been implicated in pattern formation during limb regeneration. To cite this article: A. Kumar et al., C. R. Biologies 330 (2007).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Comptes Rendus Biologies - Volume 330, Issues 6–7, June–July 2007, Pages 485–490
نویسندگان
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