کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785834 | 1645505 | 2015 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cerebrovascular adaptations to chronic hypoxia in the growth restricted lamb
ترجمه فارسی عنوان
سازگاری مغز و اعصاب با هیپوکسی مزمن در بره های محدود بر رشد
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کلمات کلیدی
IUGRGMHalpha-SMAHIFgerminal matrix haemorrhageSVZIVHCBFFGRWhite matter injury - آسیب سفید مادهalpha smooth muscle actin - آلفا آکتیو عضله صافcerebral blood flow - جریان خون مغزیintraventricular haemorrhage - خونریزی داخل وریدیBlood vessels - رگ های خونیblood brain barrier - سد خونی مغزیBBB - سد خونی مغزیNeurovascular - عصبی عضلانیHypoxia-inducible factor - فاکتور القاء کننده هیپوکسیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)cerebral palsy - فلج مغزیSubcortical white matter - ماده سفید سفالیPeriventricular white matter - ماده سفید پرویوتریالFetal growth restriction - محدودیت رشد جنینintrauterine growth restriction - محدودیت رشد داخل رحمیsubventricular zone - منطقه فرعیCapillaries - موی سر
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Chronic moderate hypoxia induces angiogenic adaptation in the brain, reflecting a modulatory role for oxygen in determining cerebrovascular development. Chronic intrauterine fetal hypoxia, such as occurs in intrauterine growth restriction (IUGR) is likely to lead to a reduction in oxygen delivery to the brain and long-term neurological abnormalities. Thus we investigated whether vascular remodeling and vascular abnormalities were evident in the brain of IUGR newborn lambs that were chronically hypoxic in utero. Single uterine artery ligation (SUAL) surgery was performed in fetuses at â¼105 days gestation (term â¼145 days) to induce placental insufficiency and IUGR. Ewes delivered naturally at term and lambs were euthanased 24 h later. IUGR brains (n = 9) demonstrated a significant reduction in positive staining for the number of blood vessels (laminin immunohistochemistry) compared with control (n = 8): from 1650 ± 284 to 416 ± 47 cells/mm2 in subcortical white matter (SCWM) 1793 ± 298 to 385 ± 20 cells/mm2 in periventricular white matter (PVWM), and 1717 ± 161 to 405 ± 84 cells/mm2 in the subventricular zone (SVZ). The decrease in vascular density was associated with a significant decrease in VEGF immunoreactivity. The percentage of blood vessels exhibiting endothelial cell proliferation (Ki67 positive) varied regionally between 14 to 22% in white matter of control lambs, while only 1-3% of blood vessels in IUGR brains showed proliferation. A 66% reduction in pericyte coverage (α-SMA and desmin) of blood vessels was observed in SCWM, 71% in PVWM, and 73% in SVZ of IUGR lambs, compared to controls. A reduction in peri-vascular astrocytes (GFAP and laminin) was also observed throughout the white matter of IUGR lambs, and extravasation of albumin into the brain parenchyma was present, indicative of increased permeability of the blood brain barrier. Chronic hypoxia associated with IUGR results in a reduction in vascular density in the white matter of IUGR newborn brains. Vascular pericyte coverage and peri-vascular astrocytes, both of which are essential for stabilisation of blood vessels and the maintenance of vascular permeability, were also decreased in the white matter of IUGR lambs. In turn, these vascular changes could lead to inadequate oxygen supply and contribute to under-perfusion and increased vulnerability of white matter in IUGR infants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 45, October 2015, Pages 55-65
Journal: International Journal of Developmental Neuroscience - Volume 45, October 2015, Pages 55-65
نویسندگان
Margie Castillo-Melendez, Tamara Yawno, Beth J. Allison, Graham Jenkin, Euan M. Wallace, Suzanne L. Miller,