کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2786196 | 1568409 | 2012 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Alteration of brain volume in IL-6 overexpressing mice related to autism Alteration of brain volume in IL-6 overexpressing mice related to autism](/preview/png/2786196.png)
Abnormal neuroimmune responses have been reported to be associated with autism and could be appropriate targets for pharmacologic intervention. Our previous studies showed that neuroimmune factor, interleukin (IL)-6, was significantly elevated in the fontal cortex and cerebellum of autistic subjects. The IL-6 overexpressing mice displayed several autism-like features as well as an abnormal dendritic spine morphology and synaptic function. The purpose of this study was to examine the volumetric differences in the brain of IL-6 overexpressing mice and compare with corresponding control mice using magnetic resonance imaging. Here we show that IL-6 overexpressing mice display an increase in the total brain volume. In addition, the lateral ventricle is also enlarged in the IL-6 overexpressing mice. The brain structures surrounding the lateral ventricle were squeezed and deformed from the normal location. These results indicate that IL-6 elevation in the brain could mediate neuroanatomical abnormalities. Taking together with our previous findings, a mechanism by which IL-6 may be involved in the pathogenesis of autism is proposed.
► IL-6 overexpressing mice display an increase in the total brain volume.
► The lateral ventricle is also enlarged in the IL-6 overexpressing mice. The brain structures surrounding the lateral ventricle were squeezed and deformed from the normal location.
► A mechanism by which IL-6 may be involved in the pathogenesis of autism is proposed.
Journal: International Journal of Developmental Neuroscience - Volume 30, Issue 7, November 2012, Pages 554–559