کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2787145 | 1568448 | 2007 | 7 صفحه PDF | دانلود رایگان |
Prenatal exposure of pregnant dams to oscillating magnetic fields can cause behavioural deficits in their offspring which persist into adulthood. These changes are waveform-specific and may involve nitric oxide. To investigate the interaction between nitric oxide modulation and perinatal magnetic fields, dams were exposed from 2 days before to 14 days after birth to one of six magnetic field conditions (1, 5, 10, 50 or 500 nT or sham) and given either water, 1 g/L nitric oxide precursor l-arginine or 0.5 g/L nitric oxide synthase inhibitor n-methylarginine. At weaning (22d), their offspring were placed in the open field for observation. Rats given 50 nT field or 500 nT field + water were hyperactive and showed increased rearing and bodyweight. These strong effects were attenuated or absent in groups given 50 or 500 nT field + n-methylarginine. Groups given sham field + l-arginine were behaviourally similar to animals given 50 or 500 nT field + water. Higher intensity fields showed robust behavioural and physiological effects. In general, these effects were counteracted by co-administration of nitric oxide synthase inhibitor n-methylarginine, which had little effect on its own. Shams given NO precursor l-arginine were highly similar to those given any higher intensity magnetic field. Results support a critical developmental role of NO and the involvement of NO in magnetic field effects.
Journal: International Journal of Developmental Neuroscience - Volume 25, Issue 7, November 2007, Pages 433–439