کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2790415 1154572 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Stereology and the Placenta: Where's the Point? – A Review
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Stereology and the Placenta: Where's the Point? – A Review
چکیده انگلیسی

The value of stereology for describing the three-dimensional (3D) structural composition and spatial arrangement of biological specimens from essentially two-dimensional (2D) thin sections is indisputable. By allowing economical quantitation of microscopical sections, stereology facilitates interpretations of normal and perturbed structure from the whole organ down to the subcellular levels. It incorporates the essential features of all sound study designs: (i) randomised sampling which is efficient and unbiased, and (ii) estimation tools which are simple, precise and unbiased or minimally biased. With these sampling and estimation tools, stereology offers a sure and safe option for characterising the total volumes, surfaces and lengths of placental compartments, the total numbers and mean sizes of nuclei or cells, and the spatial arrangements of tissues or intracellular ingredients. This review identifies the basic features of the stereological approach before indicating several ways in which stereology has been used to aid the description and interpretation of placental functional morphology from the whole organ to the molecular level. Examples include diffusive transport, villous growth, fetoplacental angiogenesis, trophoblast turnover, arterial vascular remodelling and high-resolution immunolocalisation studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 27, Supplement, April 2006, Pages 17–25
نویسندگان
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