کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2790422 1154572 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats – A Review
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Fetal Programming: Causes and Consequences as Revealed by Studies of Dietary Manipulation in Rats – A Review
چکیده انگلیسی

During pregnancy, the developing fetus is dependent on its mother for all nutritional requirements. It is not surprising, therefore, that variations in maternal nutrition can be reflected in alterations in fetal health and well-being. Interestingly, the changes can persist into adulthood and may result in increased risk of diseases such as diabetes, obesity and cardiovascular disease. The first observations of these phenomena resulted in the development of hypotheses collectively brought under the heading of “fetal” or, more recently, “developmental” programming. In this review, we will examine some of the animal models used to understand the mechanisms involved and attempt to determine whether there are common, “gatekeeper”, pathways or genes, altered by the different nutritional stresses. We will concentrate primarily on nutrition related to post-natal development of hypertension and will restrict the review to studies in rodents, since that is where most of the mechanistic studies are being undertaken. Our conclusions are that, while there may well be some common gatekeeper pathways, there is also some diversity of mechanism which may contribute to the generation of the same or similar phenotypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Placenta - Volume 27, Supplement, April 2006, Pages 56–60
نویسندگان
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