کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2793814 1568730 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TC-PTP and PTP1B: Regulating JAK–STAT signaling, controlling lymphoid malignancies
ترجمه فارسی عنوان
TC-PTP و PTP1B: تنظیم سیگنالینگ JAK-STAT، کنترل بیماری های لنفاوی
کلمات کلیدی
لوسمی و لنفوم؛ JAK-STAT؛ تریروزین فسفاتاز؛ PTP1B؛ TC-PTP
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• The JAK–STAT pathway is frequently mutated in leukemia and lymphoma.
• STATs play a critical role in establishing a cell’s transcriptional program.
• PTPs PTP1B and TC-PTP regulated JAK–STAT pathways.
• PTP1B and TC-PTP mutations sequenced in leukemia and lymphoma.
• Mutations results in elevated JAK–STAT signaling and changes in gene expression.

Lymphoid malignancies are characterized by an accumulation of genetic lesions that act co-operatively to perturb signaling pathways and alter gene expression programs. The Janus kinases (JAK)–signal transducers and activators of transcription (STATs) pathway is one such pathway that is frequently mutated in leukemia and lymphoma. In response to cytokines and growth factors, a cascade of reversible tyrosine phosphorylation events propagates the JAK–STAT pathway from the cell surface to the nucleus. Activated STAT family members then play a fundamental role in establishing the transcriptional landscape of the cell. In leukemia and lymphoma, somatic mutations have been identified in JAK and STAT family members, as well as, negative regulators of the pathway. Most recently, inactivating mutations in the protein tyrosine phosphatase (PTP) genes PTPN1 (PTP1B) and PTPN2 (TC-PTP) were sequenced in B cell lymphoma and T cell acute lymphoblastic leukemia (T-ALL) respectively. The loss of PTP1B and TC-PTP phosphatase activity is associated with an increase in cytokine sensitivity, elevated JAK–STAT signaling, and changes in gene expression. As inactivation mutations in PTPN1 and PTPN2 are restricted to distinct subsets of leukemia and lymphoma, a future challenge will be to identify in which cellular contexts do they contributing to the initiation or maintenance of leukemogenesis or lymphomagenesis. As well, the molecular mechanisms by which PTP1B and TC-PTP loss co-operates with other genetic aberrations will need to be elucidated to design more effective therapeutic strategies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 82, June 2016, Pages 52–57
نویسندگان
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