کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2793998 | 1155242 | 2015 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Transcriptional regulation of the VEGF gene in dependence of individual genomic variations Transcriptional regulation of the VEGF gene in dependence of individual genomic variations](/preview/png/2793998.png)
• VEGF-overexpression is connected to advanced stage and poor survival in cancer.
• We reviewed a potential influence of VEGF-SNPs on transcriptional regulation.
• Decreasing binding specificity was observed for MZF1 in presence of +405 C-allele.
• SNP-2578-linked insertion increased number of potential TFB sites.
• Association of SNPs and TFB could be an essential part of VEGF-regulation.
Overexpression of the vascular endothelial growth factor (VEGF) gene has been associated with advanced stage and poor survival in several cancers. The majority of disease-associated VEGF-single nucleotide polymorphisms (SNPs) locate within regulatory regions. Therefore, an influence of SNPs located in the promoter/5′-untranslated region (5′UTR) on transcription factor binding (TFB) and gene expression seems feasible.We reviewed the literature investigating a potential connection of VEGF-SNPs and transcriptional regulation of the VEGF gene. In addition, we employed transcription factor databases to search for VEGF-SNPs which have already been associated with diseases. The objective of this review is to gain an overview about an association of VEGF-SNPs and the transcription factor dependent regulation of the VEGF gene.A decreasing binding specificity of the transcription factor MZF1 in presence of the VEGF-SNP +405 C-allele has been reported. TF databases indicated a potential HIF binding site for the −2578 C-allele representing an important potential inducer of VEGF expression. Additionally, linkage disequilibrium of the −2578 A-allele and an 18 bp insertion increases the number of potential TFB sites. For the VEGF promoter SNP −1154 A/G an interaction with the HRE under participation of the SNP +405 C/G was supposed.The comprehension of the association of specific SNPs and TFB could be an essential part in our understanding of individual differences of VEGF regulation and course of diseases.
Journal: Cytokine - Volume 76, Issue 2, December 2015, Pages 519–526