Regulation of the mouse gene encoding TAFI by TNFα: Role of NFκB binding site

► Liver TAFI expression increases in acute phase in mice but mechanism is unknown. ► We demonstrate that mouse TAFI transcription is increased by TNFα. ► TNFα acts through an NFκB site in the mouse promoter that is absent in human. ► Our findings rationalize the species-specific response of TAFI levels to endotoxin.