کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2794430 1155284 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokines and irritable bowel syndrome: Where do we stand?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cytokines and irritable bowel syndrome: Where do we stand?
چکیده انگلیسی

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, which presents with one or more gastrointestinal symptoms without any structural or organic abnormality. The etiology and pathophysiological mechanisms of IBS remain uncertain. Residual or reactivated inflammation at the molecular level is considered the underlying mechanism of post-infectious IBS. On the other hand, genetic variations in the immunological components of the body, including cytokine gene polymorphisms, are proposed as a potential mechanism of IBS even in patients without previous gastrointestinal infection. Several studies have suggested imbalanced cytokine signaling as an etiology for IBS. In this review, recent findings on cytokine profiles and cytokine gene polymorphisms in patients with IBS are described and the role of cytokines in animal models of IBS is discussed.


► Cytokines are involved in the regulation of gastrointestinal functions.
► Cytokine profile is altered in patients with irritable bowel syndrome.
► Cytokines gene polymorphisms are seen in patients with irritable bowel syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 57, Issue 2, February 2012, Pages 201–209
نویسندگان
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