کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2794810 1155300 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracellular calcium level is upregulated by interleukin-32 in auditory cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Intracellular calcium level is upregulated by interleukin-32 in auditory cells
چکیده انگلیسی
Interleukin (IL)-32 has been associated with inflammation, apoptosis, and chemokine induction. The intracellular Ca2+ concentration of mammalian endolymph in the inner ear is required for normal hearing and balance. Here, we document for the first time that IL-32 highly increased intracellular calcium level and IL-1β expression in an auditory cell line, HEI-OC1 cells. Treatment with 1, 2-bis (2-aminophenoxy) ethane-N, N, N', N'-tetraacetic acid acetoxymethyl ester, a chelator of intracellular calcium, inhibited IL-32-induced IL-1 β production and caspase-1 activation. Thus, IL-32 may contribute to modulation of the inflammatory reaction through the regulation of intracellular Ca2+ in the inner ear.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 53, Issue 2, February 2011, Pages 153-157
نویسندگان
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