کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2794811 | 1155300 | 2011 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mathematical relationship between cytokine concentrations and pathogen levels during infection
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کلمات کلیدی
TNFαCFUMCP-1IL-1βIL-18IFNγinterferon γ - اینترفرون γInterleukin-18 - اینترلوکین ۱۸Interleukin-1β - اینترلوکین-1βBioinformatics analysis - تجزیه و تحلیل بیوانفورماتیکCytokine - سیتوکینBacterial infection - عفونت باکتریاییtumor necrosis factor - فاکتور نکروز تومورmonocyte chemotactic protein 1 - پروتئین chemotactic monocyte 1colony forming unit - کلنی واحد تشکیل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mathematical relationship between cytokine concentrations and pathogen levels during infection Mathematical relationship between cytokine concentrations and pathogen levels during infection](/preview/png/2794811.png)
چکیده انگلیسی
The relationship between concentrations of cytokines and microbial pathogen levels during infection is not clear. In a sub-lethal murine infection model using Gram-negative bacterial pathogen Yersinia pseudotuberculosis, the serum concentrations (C) of pro-inflammatory cytokines tumor necrosis factor α (TNFα), interferon γ (IFNγ), interleukine-1β (IL-1β) and interleukine-18 (IL-18) formed a mathematical relationship with the splenic pathogen levels (P) as measured by colony forming unit. Naming parameters “m” and “k” for magnitude and kinetics, respectively, the relationship is depicted as C = mPk. When reanalyzing the TNFα and IFNγ concentrations and the bacterial levels that were determined by other groups during infection with another strain of Y. pseudotuberculosis or with Yersinia pestis, this relationship was maintained. Interestingly, the changes in the values of “m” and “k” were consistent with the progress of the host immune response during infection; while deviation from this relationship was observed in individuals that seemed to be unable to control infection. Furthermore, in a murine model of ricin intoxication the local concentrations of the cytokine monocyte chemotactic protein 1 (MCP-1) and the concentrations of injected castor bean toxin ricin also conform to this relationship. C = mPk could be a general relationship in host cytokine response to pathogens or pathogen-associated molecular patterns. If confirmed, this type of analysis will be very useful in identifying the steps in a host immune response with which a pathogen interferes. It will also help to determine the specific functions of a host factor in the immune response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 53, Issue 2, February 2011, Pages 158-162
Journal: Cytokine - Volume 53, Issue 2, February 2011, Pages 158-162
نویسندگان
Yue Zhang, James B. Bliska,