کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2795109 1155311 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
STAT3 induces muscle stem cell differentiation by interaction with myoD
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
STAT3 induces muscle stem cell differentiation by interaction with myoD
چکیده انگلیسی
Signal transducers and activators of transcription (STAT) family proteins transduce pivotal biological effects of various cytokines and hormones. STAT3 proteins are known to play a central role in the regulation of growth, differentiation, and survival of many types of cells. However, the function of STAT3 in myogenesis still remains largely unknown. We now provided direct evidence that STAT3 could induce myogenic differentiation and this effect might be mediated by interaction with MyoD-the essential transcription factor during myogenic differentiation. Furthermore, leukemia inhibitory factor (LIF) might be the upstream factor which activated JAK2/STAT3 pathway to stimulate muscle cell differentiation. Taken together, these results provide a molecular basis for further understanding of the muscle regeneration mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 46, Issue 1, April 2009, Pages 137-141
نویسندگان
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