کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2795359 1155321 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
CRP-induced levels of oxidative stress are higher in brain than aortic endothelial cells
چکیده انگلیسی

C-reactive protein (CRP) has been demonstrated to induce blood–brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brain- (BEC) and aortic endothelial cells. Dichlorodihydrofluorescein measurements revealed significantly higher CRP-induced reactive oxygen species (ROS) levels in BEC. Protein expression of the CRP-receptors CD16, CD32 and of the NAD(P)H-oxidase subunit p22phox were also significantly higher in BEC. In conclusion BEC show a higher vulnerability to CRP due to increased levels of CRP receptors and the NAD(P)H-oxidase.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 50, Issue 2, May 2010, Pages 117–120
نویسندگان
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