کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2795395 | 1155323 | 2008 | 4 صفحه PDF | دانلود رایگان |
Polymorphisms in the cytokine genes have allowed for the understanding of the genetic determinants in several diseases. We investigated the polymorphism of the transforming growth factor (TGF)-β1 and IL-6 genes in relation to susceptibility to human brucellosis. We typed 82 Spanish brucellosis patients and 102 healthy controls for TGF-β1 polymorphisms in codons 10 and 25, and IL-6 promoter polymorphism at position −174 by PCR-SSP methods. The T/T G/G genotype of the TGF-β1 gene was significantly increased in patients compared to controls (49% vs. 32%) P = 0.02; OR = 1.99 (1.05–3.80) and the T/C G/G genotype was significantly less common in the patients compared to the controls (32% vs. 49%) P = 0.01; OR = 0.48 (0.25–0.92). The CC genotype of codon 10 was significantly increased in the patients who had focal forms of the disease as compared with those who did not develop focal forms (19% vs. 4%), P = 0.03; OR = 0.19 (0.02–1.10). No differences were found in the IL-6 variants between the patients and the controls. These results suggest that polymorphism of the TGF-β1 gene may be involved in susceptibility to brucellosis and to developing focal forms of the disease in a group of patients from southern Spain.
Journal: Cytokine - Volume 44, Issue 1, October 2008, Pages 18–21