کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2795576 | 1155333 | 2008 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Evaluation of the transforming growth factor β1 codon 25 (Arg → Pro) polymorphism in alcoholic liver disease Evaluation of the transforming growth factor β1 codon 25 (Arg → Pro) polymorphism in alcoholic liver disease](/preview/png/2795576.png)
Introduction: Liver cirrhosis develops only in a minority of heavy drinkers. Genetic factors may account for some variation in the progression of fibrosis in alcoholic liver disease (ALD). Transforming growth factor beta 1 (TGFβ1) is a key profibrogenic cytokine in fibrosis and its gene contains several polymorphic sites. A single nucleotide polymorphism at codon 25 has been suggested to affect fibrosis progression in patients with chronic hepatitis C virus infection, fatty liver disease, and hereditary hemochromatosis. Its contribution to the progression of ALD has not been investigated sufficiently so far. Patients and methods: One-hundred-and-fifty-one heavy drinkers without apparent ALD, 149 individuals with alcoholic cirrhosis, and 220 alcoholic cirrhotics who underwent liver transplantation (LTX) were genotyped for TGFβ1 codon 25 variants. Results: Univariate analysis suggested that genotypes Arg/Pro or Pro/Pro are associated with decompensated liver cirrhosis requiring LTX. However, after adjusting for patients’ age these genotypes did not confer a significant risk for cirrhosis requiring LTX. Conclusion: TGFβ1 codon 25 genotypes Arg/Pro or Pro/Pro are not associated with alcoholic liver cirrhosis. Our study emphasizes the need for adequate statistical methods and accurate study design when evaluating the contribution of genetic variants to the course of chronic liver diseases.
Journal: Cytokine - Volume 42, Issue 1, April 2008, Pages 18–23