کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2795611 1155335 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells
چکیده انگلیسی

Experimental autoimmune encephalomyelitis (EAE) is commonly regarded as an animal model of the human disease multiple sclerosis (MS). Pertussis toxin (PTX) is routinely used for EAE induction in mice. Besides opening the blood–brain barrier, it acts as an adjuvant causing strong expansion of antigen-specific cells after coinjection with neuroantigens in IFA. Using an IL-17 ELISPOT assay we developed previously, we investigated the capability of PTX to induce proteolipid protein peptide 139–151(PLPp)-specific Th-17 cells in the immune periphery and in the thymus after coinjection with PLPp/IFA. PTX was found to induce peripheral PLPp-specific Th-17 cells in the draining lymph node and in the spleen, but not in the thymus. Our study indicates a new mechanism by which microbial agents can initiate or maintain autoimmune reactions and supports the growing role in particular for Th-17 cells in organ-specific autoimmune diseases like multiple sclerosis or EAE.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 40, Issue 1, October 2007, Pages 35–43
نویسندگان
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