کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2795982 | 1568748 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effect of PEA on LPS inflammatory action in human adipocytes Effect of PEA on LPS inflammatory action in human adipocytes](/preview/png/2795982.png)
N-Palmitoylethanolamide (PEA) is an endogenous lipid secreted by human adipocytes that possesses numerous anti-inflammatory properties. Human adipose tissue can be subjected to modulation of its inflammatory state by lipopolysaccharide (LPS). Here we demonstrate that LPS increases the secretion of interleukin-6 (IL-6) by human mature adipocytes via activation of the NFκB pathway. This effect is not inhibited by PEA. Inversely, LPS strongly inhibits adipose cell leptin release, with PEA acting as a potentiator of this inhibitory effect. These actions are not linked to a reduction in leptin gene transcription. Thus, PEA does not have an anti-inflammatory role in the secretion of IL-6 via NFκB at the adipocyte level, but instead seems to act at the heart of the LPS-stimulated pathway, which, independently of NFκB, inhibits the secretion of leptin.
Journal: Cytokine - Volume 34, Issues 5–6, June 2006, Pages 291–296