کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796064 1568746 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Cytokine gene polymorphisms and susceptibility to cutaneous leishmaniasis in Iranian patients
چکیده انگلیسی

Cutaneous Leishmaniasis (CL) is one of the most prevalent clinical forms of leishmaniasis. Preliminary data suggest that cytokine gene polymorphisms can contribute to resistance or susceptibility to CL. Therefore, we investigated the association of functional polymorphisms in four cytokine genes with susceptibility to, and clinical outcome of CL. A total of 201 patients with self-healing cutaneous leishmaniasis (SCL) and 92 asymptomatic infected controls (AIC) from Fars province as well as 58 patients with chronic cutaneous leishmaniasis (CCL) and their 688 normal controls (normal Iranian population or NIP) who were collected from the different areas of Iran were included in the study. The allele-specific oligonucleotide polymerase chain reaction (ASO-PCR) or PCR-RFLP (restriction fragment length polymorphism) methods were used for genotyping. The frequency of TNF-α −308 G → A and TNF-β +252 G → A gene polymorphisms were not different between studied groups. Distribution of IFN-γ +874 A → T and IL-4 −590 C → T polymorphism were also compared between SCl or CCL patients and their controls. IFN-γ +874 A → T polymorphism was less common in CCL patients compared to the NIP (χ2 = 12.53, p = 0.0019). Significant differences in frequency of IL-4 −590 C →T polymorphism were also found between the SCL and AIC (χ2 = 8.64, p = 0.003). In conclusion, our results suggest that functional genetic variants in the IL-4 promoter could influence the risk of developing CL while the polymorphism in the first intron of the IFN-γ gene might influence the progression of disease towards CCL.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine - Volume 35, Issues 3–4, August 2006, Pages 159–165
نویسندگان
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