کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2800261 1568912 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii)
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Expression of Wnt signaling skeletal development genes in the cartilaginous fish, elephant shark (Callorhinchus milii)
چکیده انگلیسی


• Identification of genes that encode for β-catenin, Sfrp and SOST/SOSTDC1 in cartilaginous fish.
• The elephant shark β-catenin, Sfrp and SOST/SOSTDC1 genes are expressed in cartilage.
• Elephant shark β-catenin protein is localized in skeletal tissues.

Jawed vertebrates (Gnasthostomes) are broadly separated into cartilaginous fishes (Chondricthyes) and bony vertebrates (Osteichthyes). Cartilaginous fishes are divided into chimaeras (e.g. ratfish, rabbit fish and elephant shark) and elasmobranchs (e.g. sharks, rays and skates). Both cartilaginous fish and bony vertebrates are believed to have a common armoured bony ancestor (Class Placodermi), however cartilaginous fish are believed to have lost bone. This study has identified and investigated genes involved in skeletal development in vertebrates, in the cartilaginous fish, elephant shark (Callorhinchus milii). Ctnnb1 (β-catenin), Sfrp (secreted frizzled protein) and a single Sost or Sostdc1 gene (sclerostin or sclerostin domain-containing protein 1) were identified in the elephant shark genome and found to be expressed in a number of tissues, including cartilage. β-catenin was also localized in several elephant shark tissues. The expression of these genes, which belong to the Wnt/β-catenin pathway, is required for normal bone formation in mammals. These findings in the cartilaginous skeleton of elephant shark support the hypothesis that the common ancestor of cartilaginous fishes and bony vertebrates had the potential for making bone.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 193, 1 November 2013, Pages 1–9
نویسندگان
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