Update on ghrelin biology in birds

• Ghrelin is a growth hormone–releasing, appetite-stimulating hormone.
• We summarize findings regarding the ghrelin system in birds since 2008.
• Effect of peripheral ghrelin depends on chicken strain and light conditions.
• Functions of des-acyl ghrelin and obestatin need to be carefully examined.
• Relevance of ghrelin in avian-specific behavior is unknown.

Ghrelin is a peptide found in the mucosal layer of the rat stomach that exhibits growth hormone–releasing and appetite-stimulating activities. Since the discovery of ghrelin in chicken in 2002, information on its structure, distribution, function, and receptors has been accumulated, mainly in poultry. Here, we summarize the following findings since 2008 in birds: (1) central ghrelin acts as an anorexigenic neuropeptide, but the effect of peripheral ghrelin differs depending on the chicken strain and light conditions the birds are kept in; (2) central ghrelin inhibits not only food intake but also water drinking, and it may be mediated by urocortin, a member of the corticotropin-releasing factor family; (3) peripheral ghrelin acts as an anti-lipogenic factor in broiler chickens but not in rats; (4) the enzyme involved in ghrelin acylation (ghrelin-O-acyltransferase [GOAT]) has been identified in chickens; (5) dietary lipids are used for ghrelin acylation; (6) des-acyl ghrelin administered alone or with ghrelin does not affect feeding behavior; (7) the existence and physiological function of obestatin must now be carefully examined in birds; (8) other than the growth hormone secretagogue receptors (GHS) R1a and 1b, GHS-R variants not found in mammals have been found in chicken and Japanese quail; and finally (9) little is known about the involvement of the ghrelin system in wild birds and in avian-specific behavior such as brooding and migration.