کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2801766 1568932 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of nerve growth factor and its receptor in the morphogenesis of neural tube in early chick embryo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Role of nerve growth factor and its receptor in the morphogenesis of neural tube in early chick embryo
چکیده انگلیسی

Expression of p75 nerve growth factor receptor (p75NTR) in the early neurogenesis of chick embryo showed that nerve growth factor receptor (NGFR) is localized in presumptive neuroectoblast and endoblast in the chick gastrula but not in the mesoblast. By stages 9, 10, and 11, NGFR positive cells were located distinctly in the region where the neural folds converge, meet and fuse. NGFR expression was also seen in developing notochord and somites, wherein the reaction was localized on the cell surfaces. Strong p75NTR reaction was seen on the roof of the neural tube where it detaches from the head ectoderm by stage 12. The study revealed that p75NTR is co-expressed with NGF in the same developmental stage(s) and in areas, where cell death occurs during neuronal development. Further, when the endogenous levels of NGF signaling were blocked by anti-NGF antibody, abnormalities were observed at the anterior end of the neural tube formation. As a result, embryos showed open neural tubes and a few were bent on one side of the body axis. In a small proportion of embryos, diffused somites were observed. The findings supports and confirms our previous study that NGF signaling plays a significant role in the shaping of neural tube in chick embryos through p75NTR–NGF receptor.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 153, Issues 1–3, August–September 2007, Pages 141–146
نویسندگان
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