کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2801905 1156180 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: The chicken TSHR gene revisited
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Identification of unique thyrotropin receptor (TSHR) splice variants in the chicken: The chicken TSHR gene revisited
چکیده انگلیسی

We previously described the cloning of the full-length chicken thyrotropin receptor (TSHRa) and two splice variants, lacking exon 3 (TSHRb) or both exons 2 and 3 (TSHRc). Here we report the identification of three novel splice variants of the chicken TSHR, named TSHRd, -e and -f, differing in their C-terminal region and containing unique exonic sequences that are not present in the other TSHR variants. This finding suggests a TSHR gene structure with 13 rather than the previously assumed 10 exons. The three novel exons appear to be chicken-specific, as no equivalents of these exons were found in other vertebrate genomes. Like the full-length receptor, the five TSHR splice variants are most abundantly expressed in thyroid gland. TSHRb, -d, -e and -f mRNA was also present in virtually all extra-thyroidal tissues expressing TSHRa, whereas TSHRc shows a more restricted tissue distribution. Whether these receptor transcripts are translated to functional proteins needs to be verified, but if so, they could be attributed various physiological roles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 156, Issue 3, 1 May 2008, Pages 460–463
نویسندگان
, , , , , ,