کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2801947 | 1568933 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Low salinity acclimation and thyroid hormone metabolizing enzymes in gilthead seabream (Sparus auratus)
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigated the effect of acclimation to low salinity water of gilthead seabream (Sparus auratus), a euryhaline seawater teleost, on the activities of thyroid hormone-metabolizing enzymes in gills, kidney, and liver. Following acclimation to low salinity water, the plasma free thyroxine (T4) concentration increases 2.5-fold, and outer ring deiodination activities towards T4, 3,5,3â²-triiodothyronine (T3) and 3,3â²,5â²-triiodothyronine (reverse T3, rT3) in the gills are reduced by 20-32%. Conjugation (catalyzed by sulfotransferase and UDP-glucuronyltransferase) and deconjugation pathways (arylsulfatase, β-glucuronidase) play a role in the biological activity of native and conjugated thyroid hormones. Branchial, renal, and hepatic activities of the enzymes involved in these metabolic pathways respond differentially to low salinity conditions. The results substantiate that thyroid hormones are involved in S. auratus osmoregulation, and that the gills are well equipped to play an important role in the modulation of plasma hormone titers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 152, Issues 2â3, JuneâJuly 2007, Pages 215-222
Journal: General and Comparative Endocrinology - Volume 152, Issues 2â3, JuneâJuly 2007, Pages 215-222
نویسندگان
Peter H.M. Klaren, José M. Guzmán, Sjoerd J. Reutelingsperger, Juan M. Mancera, Gert Flik,