کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2803071 1156721 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Clinical osteoarthritis predicts physical and psychological QoL in acromegaly patients
چکیده انگلیسی

ObjectiveQuality of life is decreased in patients with long-term control of acromegaly. In addition, these patients suffer from irreversible osteoarthritis. The aim of this study was to assess the impact of joint-specific complaints, clinical and radiological signs of arthropathy on different aspects of quality of life (QoL) in patients with acromegaly after long-term disease control.DesignCross-sectional study.MethodsWe studied 58 patients (31 males), mean age 60 years (range 32–81 years), with strict biochemical control of acromegaly for a mean duration of 15 years. QoL was assessed by four health-related QoL questionnaires (HADS, MFI-20, NHP, SF-36) and one disease specific QoL questionnaire (AcroQoL). The outcomes of these questionnaires were compared with joint-specific self-reported complaints of pain/stiffness, clinical osteoarthritis based on American College of Rheumatology (ACR) and radiological osteoarthritis based on the Kellgren-Lawrence (KL) scoring method.ResultsLong-term cured acromegaly patients had high pain scores of the spine, knee, and hip which limited physical functioning (mean difference −27.0, 95%-CI −9.5, −41.0) and psychological well-being (mean difference −44.4, 95%-CI −26.1, −60.9) (SF-36). Clinical osteoarthritis of the spine was associated mostly with impaired QoL scores, on physical, social, and emotional functioning, and on anxiety and depression. Remarkably, radiological osteoarthritis was not associated with impaired QoL.ConclusionThese findings accentuate the importance of recognition of the clinical manifestations of arthropathy in patients with acromegaly despite long-term disease control.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 20, Issue 3, June 2010, Pages 226–233
نویسندگان
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