کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2803618 1568960 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: A randomised controlled trial
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Effects of growth hormone and/or testosterone on very low density lipoprotein apolipoprotein B100 kinetics and plasma lipids in healthy elderly men: A randomised controlled trial
چکیده انگلیسی

ObjectiveTo assess the effects of low dose recombinant growth hormone (GH), testosterone (T) and combined GH and T, on lipid profiles and very low density lipoprotein apolipoprotein B (VLDL apoB) metabolism.Design and patientsSixty-nine healthy elderly men (65–80 yr) were studied in a six month double-blind, placebo-controlled trial. Participants were randomised to placebo GH and placebo T (P), GH and placebo T (GH), T and placebo GH (T) or GH and T (GHT).MeasurementsPlasma lipid profiles were assessed before treatment and at 6 months. VLDL apoB absolute secretion rate (ASR) and fractional catabolic rate (FCR) were measured in a subset of 21 men: P (n = 5); GH (n = 5); T (n = 6); GHT (n = 5), with an infusion of 1-13C leucine. Fat mass (FM) was measured by DEXA and intra-abdominal fat (IAF) by CT scan.ResultsIGF-I levels increased in the GH and GHT (P < 0.001) groups: testosterone increased in the T (P = 0.029) and GHT (P = 0.05) groups. There was no change in total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B or lipoprotein(a) in the GH, GHT or T groups. In the subset of 21 men, IGF-I levels increased similarly with GH and GHT (P < 0.01) but T levels increased only with T (P < 0.03). FM and IAF decreased significantly only with GHT (P < 0.01, P = 0.01). Treatment with GH, T or GHT had no effect on VLDL apoB ASR or VLDL FCR.ConclusionCo-administration of GH and T in near physiological doses in healthy elderly men resulted in favourable changes in body composition without altering the plasma lipid profile or VLDL apoB metabolism.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 16, Issues 5–6, October–December 2006, Pages 308–317
نویسندگان
, , , , , ,