Association between serum uric acid related genetic loci and diabetic kidney disease in the Chinese type 2 diabetes patients

AimWe aimed to investigate the association between uric acid related genetic loci and DKD susceptibility in type 2 diabetes patients.MethodsSeventeen single nucleotide polymorphisms (SNPs) from thirteen loci related to serum uric acid were genotyped in 2,892 type 2 diabetes patients. Associations between SNPs and uric acid, SNPs and quantitative traits related to DKD or its susceptibility were evaluated.ResultsIn this study, uric acid showed a strong association with DKD (OR = 1.006, p < 0.0001). GCKR rs780094, SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142, SLC22A12 rs505802 and NRXN2 rs506338 were positively associated with serum uric acid (p = 3.79E-05, 0.0002, 2.04E-10, 2.23E-09, 0.0018 and 0.0015, respectively). SLC2A9 rs11722228 and SF1 rs606458 were significantly associated with DKD (OR = 0.864, p = 0.0440; OR = 1.223, p = 0.0038). SLC2A9 rs3775948 and ABCG2 rs2231142 were associated with DKD marginally (OR = 0.878, p = 0.0506; OR = 0.879, p = 0.0698). SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 and SF1 rs606458 were significantly associated with the estimated glomerular filtration rate (p = 0.0005, 0.0006, 0.0003, and 0.0424, respectively).ConclusionsOur study indicated that the uric acid related alleles of SLC2A9 rs11722228, SLC2A9 rs3775948, ABCG2 rs2231142 might affect DKD susceptibility and possibly through non-uric acid pathway in the Chinese people with type 2 diabetes.