کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2804246 1156861 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Role of advanced glycation end product receptors in the pathogenesis of diabetic retinopathy
چکیده انگلیسی

ProblemAdvanced glycation end products (AGEs) and the interaction with their receptors (RAGE) play an important role in the pathogenesis of diabetic retinopathy (DR). Our study investigated whether serum soluble (s) RAGE (sRAGE) could serve as a prognostic tool for identifying the susceptibility to DR. Moreover, we examined the association between soluble forms of vascular cell adhesion molecules (sVCAM-1), nitric oxide (NO) and sRAGE levels in serum and the severity of DR.MethodsCirculating levels of sRAGE, sVCAM-1, and NO were examined in 37 type 2 diabetic patient and 20 age-matched healthy nondiabetic subjects using ELISA. The diabetic subjects were categorized as patients without retinopathy, patients with nonproliferative DR (NPDR), and patients with proliferative DR (PDR).ResultsSerum sRAGE levels were significantly lower in patients with NPDR and PDR than in healthy controls and in those without retinopathy (1331.13±126.13, 934.87±66.27 vs. 1712.69±167.3, 1833.1±153.06 pg/ml, respectively, P<.05). Serum sVCAM-1 and NO were significantly higher in diabetic patients (1310.215±54.712 vs. 616.55±12.9 ng/ml and 96.432±0.864 vs. 28.78±5.88 μmol/l, respectively, P<.05) and were positively associated with the severity of DR.ConclusionsThe results indicate that sRAGE is an endogenous protection factor against the occurrence of accelerated DR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 25, Issue 3, May–June 2011, Pages 168–174
نویسندگان
, , , ,