کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2804477 | 1156874 | 2012 | 4 صفحه PDF | دانلود رایگان |
ObjectiveThis study was to observe the difference in one-hour postload plasma glucose levels and analyze its related factors in abdominally obese men with normal glucose tolerance (NGT).DesignThis case–control study included 36 abdominally obese men (waist circumference ≥ 90 cm) and 31 non-abdominally obese men (waist circumference < 90 cm) aged 20–50 years with NGT. Cases and controls were matched in age. All subjects underwent oral glucose tolerance test with 75 g of oral anhydrous glucose.Results0.5 and 1-h postload plasma glucose levels were higher in abdominally obese group than in non-abdominally obese group (P < .05). Fasting plasma glucose (FPG), 2 and 3-h postload plasma glucose were similar in the two groups (P > .05). 1-h postload plasma glucose was positively correlated with body mass index (r = 0.454), waist circumference(WC) (r = 0.519), systolic blood pressure (r = 0.456), diastolic blood pressure (r = 0.338), triglycerides (r = 0.439), and negatively correlated with high density lipoprotein cholesterol (r = − 0.391), 1/fasting insulin (r = − 0.459), insulinogenic index (r = − 0.357) and disposition index (r = − 0.602) (P < .01). In multiple regression analysis, 1-h postload plasma glucose maintained an independent association with disposition index (β = − 1.367, P = .000), WC (β = 0.103, P = .000) and triglycerides (β = 0.185, P = .017).ConclusionsThe present study demonstrated that the level of one-hour postload plasma glucose was elevated in abdominally obese men with NGT. Besides FPG and 2-h postload plasma glucose, we must also pay attention to the measurement of one-hour postload plasma glucose. Disposition index, WC and triglycerides were independently related factors for elevated one-hour postload plasma glucose.
Journal: Journal of Diabetes and its Complications - Volume 26, Issue 6, November–December 2012, Pages 536–539