کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2808147 1157735 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuromedin U2 receptor signaling mediates alteration of sleep–wake architecture in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Neuromedin U2 receptor signaling mediates alteration of sleep–wake architecture in rats
چکیده انگلیسی

Growing evidence indicates that neuromedin U (NmU) neuropeptide system plays an integral role in mediating the stress response through the corticotrophin-releasing factor (CRF) pathways. Stress is often associated with alteration in sleep–wake architecture both in human and laboratory animals. Here, we investigated whether activation of the NmU2 receptor, a major high affinity receptor for NmU predominantly expressed in the brain, affects sleep behavior in rats. Effects of single (acute) intracebroventricular (icv) infusion of 2.5 nmol of the full agonists porcine NmU8 and rat NmU23 were assessed on sleep–wake architecture in freely moving rats, which were chronically implanted with EEG and EMG electrodes. In addition, repeated once daily administration of NmU8 at 2.5 nmol during 8 consecutive days (sub-chronic) was studied.Acute icv infusion of NmU23 elicited a robust alteration in sleep–wake architecture, namely enhanced wakefulness and suppressed sleep during the first 4 h after administration. Acute infusion NmU8 had no effect on spontaneous sleep–wake architecture. However, sub-chronic icv infusion of NmU8 increased the amount of rapid eye movement (REM) sleep and intermediate stage (IS), while decreased light sleep. Additionally, NmU8 increased transitions from sleep states towards wakefulness suggesting a disruption in sleep continuity.The present results show that central-activation of NmU2 receptor markedly reduced sleep duration and disrupted the mechanisms underlying NREM–REM sleep transitions. Given that sleep–wakefulness cycle is strongly influenced by stress and the role of NmU/NmU2 receptor signaling in stress response, the disruption in sleep pattern associated with peptides species may support at least some signs of stress.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 45, Issue 2, April 2011, Pages 165–174
نویسندگان
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