کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2808429 1157755 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduction of ischemic stroke in rat brain by alpha melanocyte stimulating hormone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Reduction of ischemic stroke in rat brain by alpha melanocyte stimulating hormone
چکیده انگلیسی

Anti-inflammatory therapy has provided hope for a new effective treatment of brain ischemic stroke. In this study, adult male Wistar rats subjected to right middle cerebral artery occlusion (MCAO) for 60 min were allocated to treatment of the anti-inflammatory compound alpha melanocyte stimulating hormone (α-MSH) or saline. Magnetic resonance imaging (MRI) and histology were used to evaluate the effects of α-MSH. MRI volumetry was performed to measure infarct size, and MRI measurements of the apparent diffusion coefficient (ADC) were performed to evaluate changes in the extra/intracellular volume ratio. Triphenyltetrazolium chloride (TTC) staining was used as a reference method to measure infarct sizes. The ADC value of the infarct area decreased significantly two days after MCAO in both groups. Simultaneously the infarct volume determined from the ADC map decreased in the α-MSH treated group compared to the control group. Five days after MCAO, ADC returned to baseline levels in both groups. The infarct volume in the α-MSH group was smaller compared to the saline treated group as demonstrated both by MRI and TTC staining. This study showed that the extra/intracellular ratio (reflected by ADC) following focal brain ischemic stroke could be affected by α-MSH. Secondly, we showed that the infarct volume was reduced by α-MSH. The volumetric dimensions of the infarct areas measured by MRI were comparable to those measured by histology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropeptides - Volume 42, Issue 3, June 2008, Pages 331–338
نویسندگان
, , , , , , ,