کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2811442 | 1569226 | 2013 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: eXclusion: Toward Integrating the X Chromosome in Genome-wide Association Analyses eXclusion: Toward Integrating the X Chromosome in Genome-wide Association Analyses](/preview/png/2811442.png)
The X chromosome lags behind autosomal chromosomes in genome-wide association study (GWAS) findings. Indeed, the X chromosome is commonly excluded from GWAS analyses despite being assayed on all current GWAS microarray platforms. This raises the question: why are so few hits reported on the X chromosome? This commentary aims to examine this question through review of the current X chromosome results in the National Human Genome Research Institute Catalog of Published Genome-Wide Association Studies (NHGRI GWAS Catalog). It will also investigate commonly cited reasons for exclusion of the X chromosome from GWAS and review the tools currently available for X chromosome analysis. It will conclude with recommendations for incorporating X chromosome analyses in future studies.
Journal: - Volume 92, Issue 5, 2 May 2013, Pages 643–647