کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812035 1569296 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Correlation of Intergenerational Family Sizes Suggests a Genetic Component of Reproductive Fitness
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Correlation of Intergenerational Family Sizes Suggests a Genetic Component of Reproductive Fitness
چکیده انگلیسی

Reproductive fitness is a complex phenotype that is a direct measure of Darwinian selection. Estimation of the genetic contribution to this phenotype in human populations is confounded by within-family correlations of sociocultural, economic, and other nongenetic factors that influence family sizes. Here, we report an intergenerational correlation in reproductive success in the Hutterites, a human population that is relatively homogeneous with respect to sociocultural factors that influence fertility. We introduce an estimator of this correlation that takes into account the presence of multiple parent-offspring pairs from the same nuclear family. Statistical significance of the estimated correlation is assessed by a permutation test that maintains the overall structure of the pedigree. Further, temporal trends in fertility within this population are accounted for. Applying these methods to the S-Leut Hutterites yields a correlation in effective family size of 0.29 between couples and their sons and 0.18 between couples and their daughters, with empirical P<1×10−6 and P=.0041, respectively. Similar results were obtained for completed families (0.31 between couples and their sons and 0.23 between couples and their daughters; empirical P<1×10−6 and P=.00059, respectively). We interpret these results as indicating a significant genetic component to reproductive fitness in the Hutterites.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 81, Issue 1, July 2007, Pages 165–169
نویسندگان
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