کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812048 1569292 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A Randomization Test for Controlling Population Stratification in Whole-Genome Association Studies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
A Randomization Test for Controlling Population Stratification in Whole-Genome Association Studies
چکیده انگلیسی

Population stratification can be a serious obstacle in the analysis of genomewide association studies. We propose a method for evaluating the significance of association scores in whole-genome cohorts with stratification. Our approach is a randomization test akin to a standard permutation test. It conditions on the genotype matrix and thus takes into account not only the population structure but also the complex linkage disequilibrium structure of the genome. As we show in simulation experiments, our method achieves higher power and significantly better control over false-positive rates than do existing methods. In addition, it can be easily applied to whole-genome association studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 81, Issue 5, November 2007, Pages 895–905
نویسندگان
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