کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812307 1569309 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis
چکیده انگلیسی

In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 78, Issue 6, June 2006, Pages 1060–1065
نویسندگان
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