کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812395 1569306 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An Expectation-Maximization Algorithm for the Analysis of Allelic Expression Imbalance
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
An Expectation-Maximization Algorithm for the Analysis of Allelic Expression Imbalance
چکیده انگلیسی

A significant proportion of the variation between individuals in gene expression levels is genetic, and it is likely that these differences correlate with phenotypic differences or with risk of disease. Cis-acting polymorphisms are important in determining interindividual differences in gene expression that lead to allelic expression imbalance, which is the unequal expression of homologous alleles in individuals heterozygous for such a polymorphism. This expression imbalance can be detected using a transcribed polymorphism, and, once it is established, the next step is to identify the polymorphisms that are responsible for or predictive of allelic expression levels. We present an expectation-maximization algorithm for such analyses, providing a formal statistical framework to test whether a candidate polymorphism is associated with allelic expression differences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 79, Issue 3, September 2006, Pages 539–543
نویسندگان
, , ,