کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812479 1569314 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Screening for Recently Selected Alleles by Analysis of Human Haplotype Similarity
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Screening for Recently Selected Alleles by Analysis of Human Haplotype Similarity
چکیده انگلیسی

There is growing interest in the use of haplotype-based methods for detecting recent selection. Here, we describe a method that uses a sliding window to estimate similarity among the haplotypes associated with any given single-nucleotide polymorphism (SNP) allele. We used simulations of natural selection to provide estimates of the empirical power of the method to detect recently selected alleles and found it to be comparable in power to the popular long-range haplotype test and more powerful than methods based on nucleotide diversity. We then applied the method to a recently selected allele—the sickle mutation at the HBB locus—and found it to have a signal of selection that was significantly stronger than that of simulated models both with and without strong selection. Using this method, we also evaluated >4,000 SNPs on chromosome 20, indicating the applicability of the method to regional data sets.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 78, Issue 1, January 2006, Pages 153–159
نویسندگان
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