کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2812580 1569310 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coverage and Power in Genomewide Association Studies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Coverage and Power in Genomewide Association Studies
چکیده انگلیسی

The ability of genomewide association studies to decipher genetic traits is driven in part by how well the measured single-nucleotide polymorphisms “cover” the unmeasured causal variants. Estimates of coverage based on standard linkage-disequilibrium measures, such as the average maximum squared correlation coefficient (r2), can lead to inaccurate and inflated estimates of the power of genomewide association studies. In contrast, use of the “cumulative r2 adjusted power” measure presented here gives more-accurate estimates of power for genomewide association studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 78, Issue 5, May 2006, Pages 884–888
نویسندگان
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