کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2813953 1569490 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Turner syndrome and meningioma: Support for a possible increased risk of neoplasia in Turner syndrome
ترجمه فارسی عنوان
سندرم ترنر و مننژیوم: حمایت از احتمال خطر افزایش نئوپلازی در سندرم ترنر
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی

Neoplasia is uncommon in Turner syndrome, although there is some evidence that brain tumors are more common in Turner syndrome patients than in the general population. We describe a woman with Turner syndrome (45,X) with a meningioma, in whom a second neoplasia, basal cell carcinomas of the scalp and nose, developed five years later in the absence of therapeutic radiation. Together with 7 cases of Turner syndrome with meningioma from a population-based survey in the United Kingdom, and 3 other isolated cases in the literature, we review this small number of patients for evidence of risk factors related to Turner syndrome, such as associated structural anomalies or prior treatment. We performed histological and fluorescent in situ hybridization (FISH) of 22q (NF2 locus) analyses of the meningeal tumor to search for possible molecular determinants. We are not able to prove causation between these two entities, but suggest that neoplasia may be a rare associated medical problem in Turner syndrome. Additional case reports and extension of population-based studies are needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medical Genetics - Volume 57, Issue 6, May–June 2014, Pages 269–274
نویسندگان
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