کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2815162 1159855 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genotypic distribution of common variants of endosomal toll like receptors in healthy Spanish women. A comparative study with other populations
ترجمه فارسی عنوان
توزیع ژنوتیپ از انواع رایج عوارض اندوسومی مانند گیرنده ها در زنان سالم اسپانیایی. مطالعه تطبیقی ​​با سایر جمعیت ها
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی


• We describe genotype frequencies of endosomal TLR polymorphisms in Spaniard females.
• Genotype distributions are quite different when compared with Asiatics.
• Differences are also found when comparing with Caucasian populations.
• Highly matched ethnicity is mandatory to probe disease susceptibility of these genes.

Genetic variants of endosomal toll like receptors (TLR) have been associated with many infectious, autoimmune and inflammatory diseases, but few studies have been reported in the Spanish population. The aim of this study was to describe the allelic and genotypic distributions of some common nucleotide substitutions of endosomal TLRs in healthy Spanish women and to compare them with those already published in other population groups. Nine substitutions were analysed in 150 DNA samples from 150 Spanish, non-related healthy females: TLR3 rs3775291 and rs5743305; TLR7 rs179008 and rs5743781; TLR8 rs3764880 and TLR9 rs187084, rs5743836, rs352139 and rs352140.Genotyping was carried out by real time PCR and melting curve analysis in a LightCycler 480. A systematic review was performed in order to compare the genotypic distributions in our cohort with those previously published in other population groups. The comparative study was performed with the two tailed Fisher's test or the Yates continuity correction for the Chi-square test when appropriate. No homozygotes for rs5743781 in TLR7 were found, and rs352139 and rs352140 of TLR9 were in strong linkage disequilibrium. Genotype distributions in endosomal TLR are similar to other Spanish series previously reported. As expected, most differences were found when comparing our distributions with Asiatics, but differences were also found with other Caucasian populations. Since there are significant variations in genotypic distributions of TLRs in both interracial groups and within the same ethnic group, to carry out studies of disease susceptibility in more restricted groups is mandatory.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 578, Issue 1, 1 March 2016, Pages 32–37
نویسندگان
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