کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2815250 | 1159862 | 2016 | 13 صفحه PDF | دانلود رایگان |
• Myosin superfamily's functions have been summarized in spermatogenesis.
• The relationship between myosins and testicular tumor has been illustrated.
• Recent studies and controversial theories have been summarized exhaustively.
• Myosin signaling molecules' relationship in spermatogenesis was specified in model.
Spermatogenesis is a fundamental process in sexual development and reproduction, in which the diploid spermatogonia transform into haploid mature spermatozoa. This process is under the regulation of multiple factors and pathway. Myosin has been implicated in various aspects during spermatogenesis. Myosins constitute a diverse superfamily of actin-based molecular motors that translocate along microfilament in an ATP-dependent manner, and six kinds of myosins have been proved that function during spermatogenesis. In mitosis and meiosis, myosins play an important role in spindle assembly and positioning, karyokinesis and cytokinesis. During spermiogenesis, myosins participate in acrosomal formation, nuclear morphogenesis, mitochondrial translocation and spermatid individualization. In this review, we summarize current understanding of the functions of myosin in spermatogenesis and some reproductive system diseases such as testicular tumors and prostate cancer, and discuss the roles of possible upstream molecules which regulate myosin in these processes.
Journal: Gene - Volume 576, Issue 1, Part 2, 15 January 2016, Pages 195–207