Keywords: MAP، پروتئین فعال mitogen; AMPK, AMP-activated protein kinase; AR, androgen receptors; AT, acrosomal tubule; EV, endoplasmic reticulum vesicle; IC, individualization complex; MAP, mitogen-activated protein; MLCK, myosin light chain kinase; MYPT1, myosin phosphatase targeting subuni
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Lipopolysaccharide of Aggregatibacter actinomycetemcomitans induces the expression of chemokines MCP-1, MIP-1α, and IP-10 via similar but distinct signaling pathways in murine macrophages
Keywords: MAP، پروتئین فعال mitogen; AaLPS, Aggregatibacter actinomycetemcomitans LPS; BMMs, bone marrow-derived macrophages; CAT, chloramphenicol acetyltransferase; IFN-β, interferon-β; IP-10, interferon-inducible protein-10; LPS, lipopolysaccharide; MAP, mitogen-activated protein; MAPK, MA
TRAF6 is functional in inhibition of TLR4-mediated NF-κB activation by resveratrol
Keywords: MAP، پروتئین فعال mitogen; ERK, extracellular-signal-regulated kinase; IKK, inhibitor- κB (IκB) kinase; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAP, mitogen-activated protein; MyD, myeloid differentiation primary response gene; NF-κB, nuclear factor-κB; RIP, receptor
Genome-wide analysis of the WRKY gene family in physic nut (Jatropha curcas L.)
Keywords: MAP، پروتئین فعال mitogen; ERK, extracellular signal-regulated protein; EST, expression sequence tag; ETI, effector-triggered immunity; LRR, leucine-rich repeat; MAP, mitogen-activated protein; NBS, nucleotide binding site; NJ, Neighbor-joining; PAMP, pathogen associated molecular
Fibroblast growth factor signaling controlling bone formation: An update
Keywords: MAP، پروتئین فعال mitogen; FGF, Fibroblast growth factor; FGFR, Fibroblast growth factor receptor; PTH, Parathyroid hormone; BMP, Bone morphogenetic protein; MAP, Mitogen-activated protein; ERK, Extracellular signal-regulated kinases; PKC, Protein kinase C; PI3K, Phosphatidyl inosi
High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol
Keywords: MAP، پروتئین فعال mitogen; ECM, extracellular matrix; H2DCF-DA, 2′ 7′-dichlorodihydrofluorescein diacetate; HG, high glucose; MAP, mitogen-activated protein; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAC, N-acetyl cysteine; NG, normal glucose; ROS, reactive
Analytical challenges and the development of biomarkers to measure and to monitor the effects of ocean acidification
Keywords: MAP، پروتئین فعال mitogen; 7TM, Seven-transmembrane; Cox, Cyclooxygenase; DNA, deoxyribonucleic acid; ESP, Environmental Sample Processor; IPCC, Intergovernmental Panel on Climate Change; LC, Liquid chromatography; MAP, Mitogen-activated protein; MAPK, Mitogen-activated protein kin
Lymphotoxin α stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts
Keywords: MAP، پروتئین فعال mitogen; ERK, extracellular signal-regulated kinases; FLS, fibroblast-like synoviocytes; HVEM, Herpesvirus Entry Mediator; IgG, immunoglobulin G; IL, interleukin; LTα, Lymphotoxin α; MAP, mitogen-activated protein; MMP, matrix metalloproteinase; NFκB, nuclear fact
Palytoxins and cytoskeleton: An overview
Keywords: MAP، پروتئین فعال mitogen; Actin; Cytoskeleton; Microtubules; Ostreocin-D; Palytoxin; Ovatoxin-aABPs, Actin Binding Proteins; BAR, Bin/Amphiphysin/Rvs; F-actin, Filamentous actin; G-actin, Globular actin; LSC, Laser-scanning cytometer; MAP, Mitogen-activated protein; PLT, Palytoxin
X-ray crystal structure of JNK2 complexed with the p38α inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors
Keywords: MAP، پروتئین فعال mitogen; JNK2; p38; BIRB796; Protein crystallography; X-ray crystal structure; DFG-out; Protein kinase; Kinase inhibitor; Structure-based drug designJNK, c-Jun N-terminal kinase; MAP, mitogen-activated protein
Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state
Keywords: MAP، پروتئین فعال mitogen; JNK, c-Jun NH2-terminal kinase; MAP, mitogen-activated protein; MKK, MAP kinase kinase; MKKK, MAP kinase kinase kinase; IPTG, isopropyl-β-d-thiogalactopyranoside; npMKK4, non-phosphorylated MKK4 kinase domain; AMP–PNP, adenylyl-imidodiphosphate; rmsd, roo
Deciphering cellular functions of protein phosphatases by comparison of gene expression profiles in Saccharomyces cerevisiae
Keywords: MAP، پروتئین فعال mitogen; RG, Reference Gene; PPase, protein phosphatase; PKase, protein kinase; MAP, mitogen-activated protein; PCR, polymerase chain reaction; Cg, Candida glabrataSaccharomyces cerevisiae; Protein phosphatase; Expression profile; Pearson's correlation; Phenotypic
Signaling pathways induced by a tumor-derived vaccine in antigen presenting cells
Keywords: MAP، پروتئین فعال mitogen; Tumor vaccines; Dendritic cells; Macrophages; Cell signalingCRCL, chaperone-rich cell lysates; DC, dendritic cells; NF-κB, nuclear factor kappa B; NK, natural killer cells; MAP, mitogen-activated protein; MHC, major histocompatibility complex; STAT, signa
Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; MTT, 3-(4,5-dimetnyl-thiazol-2-yl)2,5-diphenyl tetrazolium bromide; FITC, fluorescein isothiocyanate; FBS, fetal bovine serum; PBS, phosphate-buffered saline; ERK, extracellular signal-regulated kinase; RT-PCR, reverse tran
Interleukin-1ß is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro
Keywords: MAP، پروتئین فعال mitogen; hMSC-Ad, human mesenchymal stem cell-derived adipocytes; IL, interleukin; Jak, janus kinase; MAP, mitogen-activated protein; NF, nuclear factor; PI, phosphatidylinositol; T2DM, type 2 diabetes mellitus; TIARP/STAMP2, tumor necrosis factor α-induced adipos
Effect of the DEF motif on phosphorylation of peptide substrates by ERK
Keywords: MAP، پروتئین فعال mitogen; ERK, extracellular signal regulated kinase; MAP, mitogen-activated protein; JNK, c-jun N-terminal kinase; His6, hexahistidine; FAM, fluorescein; AOO, 8-amino dioxaoctanoic acid; PDB, protein data bankMAP kinase; Docking motifs; FXFP motif; Peptide substra
Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure
Keywords: MAP، پروتئین فعال mitogen; NRG-1, neuregulin-1; ADAM, a-disintegrin and metalloprotease; PI-3, phosphoinositide-3; MAP, mitogen-activated protein; LV, left ventricular; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; pY, phosphotyrosine; ECD, extracellular doma
Rescue Treatment in Asthma : More Than As-Needed Bronchodilation
Keywords: MAP، پروتئین فعال mitogen; asthma control; β2-agonists; combination therapy; corticosteroidsAC, adenylyl cyclase; GR, corticosteroid receptor; ICS, inhaled corticosteroids; MAP, mitogen-activated protein; MKP, mitogen-activated protein kinase phosphatase; PRN, as required
Myocardial Survival Signaling in Response to Stem Cell Transplantation
Keywords: MAP، پروتئین فعال mitogen; ERK, extracellular signal-regulated kinase; LAD, left anterior descending; MAP, mitogen-activated protein; MSC, mesenchymal stem cell
Bile Acid Aspiration in Suspected Ventilator-Associated Pneumonia
Keywords: MAP، پروتئین فعال mitogen; CD, chenodeoxycholic acid; DC, dehydrocholic acid; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GCD, glycochenodeoxycholic acid; IL, interleukin; JNK, c-Jun N-terminal kinase; LC, lithocholic acid; MAP, mitogen-activated protein; PCR, polymerase chain
Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells
Keywords: MAP، پروتئین فعال mitogen; DMA(III), trivalent dimethylarsinous acid; iAs(III), inorganic arsenite; DMA(V), pentavalent dimethylarsinic acid; p-His H3, phospho-histone H3; MAP, mitogen-activated protein; ERK, extracellular signal-regulated kinase; MEK, MAP kinase/ERK kinase; SAC, s
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases
Keywords: MAP، پروتئین فعال mitogen; Benzophenones; Proteases; Guttiferone A; Cathepsin G; SAR; Flexible dockingCC, column chromatography; TLC, thin layer chromatography; MAP, mitogen-activated protein; XRD, X-ray diffraction; HPLC, High Performance Liquid Chromatography; Z-FR-AMC, carbobenz
p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; CDK, cyclin-dependent kinase; GSK-3, glycogen synthase kinase 3; 4-FPP, 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]pyridine; SB203580, 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-imidazole; PDB, Protein Data Bank
Challenges in cancer research and multifaceted approaches for cancer biomarker quest
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; PI3K, phosphatidylinositol-3 kinase; mTOR, mammalian target of rapamycin; Prom1, Prominin 1; EGFRs, epidermal growth factor receptors; VEGFR, vascular endothelial growth factor receptor; PDGFRs, platelet-derived growth fact
Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia
Keywords: MAP، پروتئین فعال mitogen; BTK, Bruton's tyrosine kinase; DCs, dendritic cells; IRAK, IL-1 receptor-associated kinase; FITC, fluorescein isothiocyanate; LPS, lipopolysaccharide; mAb, monoclonal antibodies; Mal, MyD88 adaptor-like protein; MAP, mitogen-activated protein; MHC, major
Epidermal Growth Factor receptor (EGFR) regulates mechanical ventilation–induced lung injury in mice
Keywords: MAP، پروتئین فعال mitogen; ALI, acute lung injury; ARDS, adult respiratory distress syndrome; BAL, bronchoalveolar lavage; DMSO, dimethyl sulfoxide; EBD, Evans blue dye; EGFR, epidermal growth factor receptor; MAP, mitogen-activated protein; MV, mechanical ventilation; PBS, phospha
The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity
Keywords: MAP، پروتئین فعال mitogen; JNK, c-Jun N-terminal kinase; MAP, mitogen-activated protein; MKK, MAP kinase kinase; PDB, Protein Data Bank; TCEP, Tris(2-carboxyethyl)phosphine hydrochloride; Mes, 4-morpholineethanesulfonic acidJNK2; MAP kinase insert; protein crystallography; site-dir
Protein phosphatase Siw14 controls intracellular localization of Gln3 in cooperation with Npr1 kinase in Saccharomyces cerevisiae
Keywords: MAP، پروتئین فعال mitogen; PPase, protein phosphatase; PKase, protein kinase; MAP, mitogen-activated protein; TOR, target of rapamycin; DAPI, 4′,6-diamidino-2-phenylindole; PCR, polymerase chain reaction; RT-PCR, reverse transcriptase-polymerase chain reaction.Yeast; Caffeine; Gln3
Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells
Keywords: MAP، پروتئین فعال mitogen; MT2A, metallothionein-2A; HO-1, heme oxygenase-1; ROS, reactive oxygen species; NAC, N-acetyl-L-cysteine; MAP, mitogen-activated protein; DCF, dichlorodihydrofluorescein; Mito-Q, mitoquinone; TPEN, N,N′,N′-tetrakis (2-pyridylmethyl)ethylenediamineGallium;
A Novel Lipid Binding Site Formed by the MAP Kinase Insert in p38α
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; MKK, MAP kinase kinase; β-OG, n-octyl-β-glucopyranoside; TAK1, transforming growth factor-β-activated protein kinase 1; SPR, surface plasmon resonance; DMSO, dimethyl sulfoxide; AA, arachidonic acid; 15(s)-HETE, 15(s)-hydro
The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; Mkp, MAP kinase phosphatase; LPS, lipopolysaccharides; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; TNF, tumor necrosis factor; IL, interleukin; ELISA, enzyme-linked immunosorbent assay; FBS, fe
Purification and mass spectrometric analysis of the κ opioid receptor
Keywords: MAP، پروتئین فعال mitogen; DDM, n-dodecyl-β-d-maltopyranoside; HEK, human embryonic kidney; HSP70, heat shock protein 70; MALDI, matrix-assisted laser desorption ionization; MAP, mitogen-activated protein; MS, mass spectrometry; rKOR, rat kappa opioid receptor; SDS/PAGE, sodium dod
Oxidation induces ClC-3-dependent anion channels in human leukaemia cells
Keywords: MAP، پروتئین فعال mitogen; ClC-3, member 3 of the cloned chloride channel family ClC; EGTA, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; MAP, mitogen-activated protein; MQAE, N-(ethoxycarbonylmethyl)-
Differential expression of HCNP-related antigens in hippocampus in senescence-accelerated mice
Keywords: MAP، پروتئین فعال mitogen; AMPA, α-amino-3-hydroxy-5-metyl-4-isoxazolepropionic acid; ChAT, choline acetyltransferase; Erk, extracellular signal-regulated kinase; HCNP, hippocampal cholinergic neurostimulating peptide; MAP, mitogen-activated protein; MEK, extracellular signal-regul
Gastrodia elata modulated activator protein 1 via c-Jun N-terminal kinase signaling pathway in kainic acid-induced epilepsy in rats
Keywords: MAP، پروتئین فعال mitogen; AP-1, activator protein 1; EEG, electroencephalogram; EMG, electromyogram; ERKs, extracellular signal-regulated kinases; HPLC, high-performance liquid chromatography; JNKs, c-Jun N-terminal kinases; KA, kainic acid; MAP, mitogen-activated protein; SD rat,
Expression and regulation of intercellular adhesion molecule-1 on airway parasympathetic nerves
Keywords: MAP، پروتئین فعال mitogen; Intercellular adhesion molecule 1; TNF-α; nuclear factor κB; dexamethasone; asthma; parasympathetic nerve; human; guinea pigc-JNK, c-Jun N-terminal kinase; ICAM-1, Intercellular adhesion molecule-1; MAP, Mitogen-activated protein; NF-κB, Nuclear factor-κB
5-HT1A receptors mediate (+)8-OH-DPAT-stimulation of extracellular signal-regulated kinase (MAP kinase) in vivo in rat hypothalamus: Time dependence and regional differences
Keywords: MAP، پروتئین فعال mitogen; 5-HT, 5-hydroxytryptamine; (+)8-OH-DPAT, (+)-8-hydroxy-2-dipropylaminotetralin; ERK, extracellular signal-regulated kinase; MAP, mitogen-activated protein; MEK, extracellular signal-regulated kinase kinase; pERK, phosphorylated extracellular signal-regula
The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen
Keywords: MAP، پروتئین فعال mitogen; ANOVA, analysis of variance; ATA, atmosphere absolute; C/EBP, CCAAT enhancer binding protein; Egr-1, early growth response protein 1; HBO, hyperbaric oxygen; HSP, heat shock protein; MABP, mean artery blood pressure; MAP, mitogen-activated protein; NGF, n
Progression of Heart Failure Was Suppressed by Inhibition of Apoptosis Signal-Regulating Kinase 1 Via Transcoronary Gene Transfer
Keywords: MAP، پروتئین فعال mitogen; ANOVA, analysis of variance; ASK1, apoptosis signal-regulating kinase 1; ERK, extracellular signal-regulated kinase; JNK, c-Jun NH2-terminal kinase; LV, left ventricular; LVPWT, left ventricular posterior wall; MAP, mitogen-activated protein; MKK, mitogen
A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells
Keywords: MAP، پروتئین فعال mitogen; ELISA, enzyme-linked immunosorbent assay; IL, interleukin; IL-21R, interleukin-21 receptor; MAP, mitogen-activated protein; PBMC, peripheral blood mononuclear cell
Structures of p38α Active Mutants Reveal Conformational Changes in L16 Loop that Induce Autophosphorylation and Activation
Keywords: MAP، پروتئین فعال mitogen; MAP, mitogen-activated protein; MKK, MAP kinase kinase; ERK, extracellular signal-regulated kinase; β-OG, n-octyl-β-glucopyranoside; KD, kinase-deadp38; mitogen activated protein kinase; active mutants; crystal structure; dimerization
Regulation of innate immune response by MAP kinase phosphatase-1
Keywords: MAP، پروتئین فعال mitogen; MKP, MAP Kinase Phosphatase; MAP, mitogen-activated protein; JNK, c-Jun N-terminal kinase; ERK, extracellular signal-regulated kinase; MK-2, MAP kinase-activated protein kinase-2; IKK, IκB kinase; IRAK, IL-1 receptor-associated kinase; LPS, lipopolysaccha
Bidirectional Signals Transduced by TOPK-ERK Interaction Increase Tumorigenesis of HCT116 Colorectal Cancer Cells
Keywords: MAP، پروتئین فعال mitogen; EGF, epidermal growth factor; ERK, extracellular signal-regulated kinase; MAP, mitogen-activated protein; MAPK, mitogen-activated protein kinase; MAPKK, mitogen-activated protein kinase kinase; TOPK, T-cell-originated protein kinase
Aprotinin inhibits proinflammatory activation of endothelial cells by thrombin through the protease-activated receptor 1
Keywords: MAP، پروتئین فعال mitogen; 25; 29; 31; 16CPB, cardiopulmonary bypass; Egr, early growth response; HRP, horseradish peroxidase; HUVEC, human umbilical vein endothelial cell; IL, interleukin; KIU, kallikrein inhibitory units; MAP, mitogen-activated protein; PAR, protease-activated re
P2X7 and phospholipid signalling: The search of the “missing link” in epithelial cells
Keywords: MAP، پروتئین فعال mitogen; TNFR1, tumour necrosis factor receptor 1; TNF, tumour necrosis factor; [Ca2+]i, intracellular concentration of calcium; ERK 1/2, extracellular-signal regulated kinase 1/2; MAP, mitogen-activated protein; PKD, protein kinase D; PKC, protein kinase C; DAG,
Novel signal transduction modulators for the treatment of airway diseases
Keywords: MAP، پروتئین فعال mitogen; Inflammation; Nuclear factor-κB; MAP kinase; Syk kinase; Phosphoinositide-3 kinaseCOPD, chronic obstructive pulmonary disease; IKK, inhibitor of nuclear factor-κB kinase; IL, interleukin; JNK, Jun-N-terminal kinase; MAP, mitogen-activated protein; NF-κB,
Discovering differential activation machinery of the Toll-like receptor 4 signaling pathways in MyD88 knockouts
Keywords: MAP، پروتئین فعال mitogen; IKK, inhibitor of nuclear factor-κB-kinase; IRAK-1, IL-1R associated kinase 1; IRF-3, interferon (IFN) regulatory factor 3; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAP, mitogen-activated protein; MKK, map kinase kinase; MyD88, myeloid diffe
Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells
Keywords: MAP، پروتئین فعال mitogen; CDK, cyclin-dependent kinase; ERK, extracellular signal-regulated kinase; GSK-3β, glycogen synthase kinase-3β; HSC, hepatic stellate cells; IGF-1, insulin-like growth factor-1; MAP, mitogen-activated protein; MEK, MAP/ERK kinase; p70-S6-K, p70-S6 kinase;
Hydrogen peroxide is a mediator of indole-3-acetic acid/horseradish peroxidase-induced apoptosis
Keywords: MAP، پروتئین فعال mitogen; AAPH, 2,2′-azobis (2-amidinopropane) dihydrochloride; DCF, dichlorofluorescein; DCFH-DA, 2,7-dichlorofluorescin diacetate; HRP, horseradish peroxidase; IAA, indole-3-acetic acid; JNK, c-Jun N-terminal kinase; MAP, mitogen-activated protein; MTT, 3-(4,5-di
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
Keywords: MAP، پروتئین فعال mitogen; BSA, bovine serum albumin; ECM, extracellular matrix; DAPI, 4,6-diamidino-2-phenylindole; DMEM, Dulbecco's modified Eagle's medium; MAP, mitogen-activated protein; MMCs, murine mesangial cells; PARP, poly (ADP-ribose) polymerase; PBS, phosphate-buffered s