کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2816053 1159912 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development
چکیده انگلیسی


• apoc1 is highly expressed during zebrafish embryogenesis.
• apoc1 expression is induced by BMP signaling.
• RA signaling suppresses the expression of BMP ligands.
• RA signaling inhibits the BMP effect on apoc1 expression.

Apolipoproteins, the major components of lipoproteins, play physiological roles in lipoprotein metabolism. Contrary to the well-documented effects on plasma lipid, little is known about the function and regulation of Apolipoproteins during embryonic development. Here we have shown that apolipoprotein C1 (apoc1) gene is highly expressed in the yolk syncytial layer, a structure implicated in embryonic and larval nutrition. The apoc1 transcripts are also observed in the deep cell layer at the ventral and lateral region during gastrulation, and in the tail paraxial mesoderm during somitogenesis. By whole-mount in situ hybridization and quantified RT-RCR, we further demonstrate that apoc1 expression is induced by bone morphogenetic proteins (BMPs) signaling, while retinoic acid (RA) signaling suppresses the expression of BMP ligands and inhibits the BMP effect in this process.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 554, Issue 2, 10 January 2015, Pages 196–204
نویسندگان
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