A behavioral study of healthy and cancer genes by modeling electrical network

• We model individual amino acid structure by passive electrical components R, L and C.
• 1st Foster network is used to design electrical system of Homo Sapiens genes.
• Model is realized to screen out cancer genes from healthy genes.
• Step and pole-zero characteristics show the unstable behavior of cancer genes.
• Network responses show dominance of hydrophilic amino acids in cancer genes.

In recent years, gene network modeling is gaining popularity in genomics to monitor the activity profile of genes. More specifically, the objective of the network modeling concept is to study the genetic behavior associated with disease. Previous researchers have designed network model at nucleotide level which produces more complexity for designing circuits mostly in case of gene expression studies. Whereas the authors have designed the present network model, based on amino acid level which is simpler as well as more appropriate for prediction of the genetic abnormality. In the present concept, SISO continuous and discrete system models of genes are realized using Foster network. The model is designed based on hydropathy index value of amino acids to study the biological system behavior. The time and phase response in continuous (s) domain and pole-zero distribution in discrete (z) domain are used as measurement metric in the present study. The simulated responses of the system show genetic instability for cancer genes which truly reflects the medical reports. The proposed modeling concept can be used, to accurately identify or separate out the diseased genes from healthy genes.

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