کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2816266 | 1159923 | 2014 | 8 صفحه PDF | دانلود رایگان |
• rgnG4035 mutant flies have higher mortality than wild-type flies after ingestion of sodium dodecyl sulfate (SDS).
• Excessive melanization and increased necrotic cells in the gut contribute to the reduced survival of rgnG4035 mutant flies.
• rgn mutant flies have a defect in the replenishment of intestinal stem cells (ISCs) following gut damage.
• The antimicrobial peptide (AMP) expression is affected in rgnG4035 mutant fly guts.
Resistance and resilience constitute the two complementary aspects of epithelial host defenses in Drosophila. Epithelial cell homeostasis is necessary for the recovery of damages caused by stress or infections. However, the genes responsible for gut epithelial homeostasis remain poorly understood. Here, we show that rgnG4035 mutant flies have higher mortality than wild-type flies after ingestion of sodium dodecyl sulfate (SDS). Excessive melanization and increased necrotic cells in the gut contribute to the reduced survival of rgnG4035 mutant flies following SDS ingestion. rgn mutant flies have a defect in the replenishment of intestinal stem cells (ISCs) following gut damage. The antimicrobial peptide (AMP) expression is affected in rgnG4035 mutant fly guts. Together, our study provides evidence that rgn gene is essential for gut cell homeostasis following damage in Drosophila.
Journal: Gene - Volume 549, Issue 1, 1 October 2014, Pages 141–148