کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2816555 | 1159941 | 2014 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies](/preview/png/2816555.png)
• RNAi is a specific post-transcriptional gene-silencing.
• It has become a potential treatment for human diseases.
• Researchers attempted to solve technical difficulties of RNAi-based therapeutics.
During recent decades there have been remarkable advances in biology, in which one of the most important discoveries is RNA interference (RNAi). RNAi is a specific post-transcriptional regulatory pathway that can result in silencing gene functions. Efforts have been done to translate this new discovery into clinical applications for disease treatment. However, technical difficulties restrict the development of RNAi, including stability, off-target effects, immunostimulation and delivery problems. Researchers have attempted to surmount these barriers and improve the bioavailability and safety of RNAi-based therapeutics by optimizing the chemistry and structure of these molecules. This paper aimed to describe the principles of RNA interference, review the therapeutic potential in various diseases and discuss the new strategies for in vivo delivery of RNAi to overcome the challenges.
Journal: Gene - Volume 538, Issue 2, 1 April 2014, Pages 217–227